CELL CULTURE METHODS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250109377A1
SERIAL NO

18728767

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Abstract

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A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite below an inhibitory concentration in the cell culture medium for the at least one metabolite, wherein the at least one metabolite is aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI), N-acetylputrescinium (NAP), or a combination thereof, and wherein the enzyme comprises ADH5, BCAT1, CAT, GOT1, HADHB, HOGA1, SLC35A1, or a combination thereof.

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Patent Owner(s)

Patent OwnerAddress
UNIV MASSACHUSETTSBOSTON MASSACHUSETTS 02108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hoang, Duc Burnsville, US 3 0
Kuang, Bingyu Worcester, US 3 0
Yoon, Seongkyu Lowell, US 4 80

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