CHIMERIC HEAVY CHAIN CONSTANT DOMAINS WITH REDUCED BINDING TO FC GAMMA RECEPTORS AND USES THEREOF
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United States of America
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Issued Date -
Apr 3, 2025
app pub date -
Apr 20, 2023
filing date -
Apr 20, 2023
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Abstract
The present disclosure relates to chimeric heavy chain constant domains having reduced effector function. Also disclosed are recombinant polypeptides comprising such chimeric heavy chain constant domains, including antibodies such as multispecific antibodies, fusion proteins, and other recombinant proteins. Nucleic acids encoding such recombinant polypeptides are also disclosed, as well as cells expressing such recombinant polypeptides and pharmaceutical compositions comprising such recombinant polypeptides.
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