EVOLVED PROTEIN DEGRONS

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250109177A1
SERIAL NO

18978484

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Abstract

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Aspects of the disclosure relate to compositions and methods for targeted protein degradation. In some embodiments, the disclosure relates to methods of evolving protein degrons to interact with certain small molecule inducers (e.g., VS-777, PT-179, or PK-1016). In some embodiments, the disclosure relates to compositions (e.g., peptides, nucleic acids encoding the protein degrons, etc.) used for targeted protein degradation. In some embodiments, the disclosure relates to methods of degrading a target polypeptide in a cell.

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Patent Owner(s)

Patent OwnerAddress
THE BROAD INSTITUTE INC415 MAIN STREET CAMBRIDGE MA 02142

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Choudhary, Amit Boston, US 34 86
Deb, Arghya Cambridge, US 3 0
DeCarlo, Stephan Cambridge, US 1 0
Kokkonda, Praveen Boston, US 7 0
Liu, David R Cambridge, US 236 9909
Mercer, Jaron August McClure Cambridge, US 1 0
Shoba, Veronika Cambridge, US 5 0
Tiwari, Praveen Boston, US 12 42
Vedagopuram, Sreekanth Boston, US 6 0

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