RECOMBINANT TYPE I ALLERGEN OF ARTEMISIA ANNUA POLLEN, AND PREPARATION METHOD AND USE THEREOF

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APP PUB NO 20250109176A1
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18725848

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A recombinant type I allergen of Artemisia annua pollen (Art a 1), a coding gene, an expression method, and a purification method thereof are provided. By different combinations of codon optimization, different signal peptides, expression vectors and strains, the Art a 1 obtained reaches the expression level of more than 200 mg/L, with a purity of more than 99%, and the activity of the Art a 1 is equivalent to that of a native protein, and the Art a 1 can be used for the desensitization immunotherapy and diagnosis of Artemisia pollen allergy.

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Patent Owner(s)

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ZONHON BIOPHARMA INSTITUTE INCCHANGZHOU JIANGSU

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GAO, Hui Changzhou, CN 54 859
MA, Bruce Yong Changzhou, CN 11 6
WANG, Qin Changzhou, CN 181 661
ZHAO, Baixue Changzhou, CN 2 0
ZHUANG, Yu Changzhou, CN 6 11

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges3496101 - 100200400600800100012001400160018002000220024002600280030003200340036003800

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