INTRACELLULAR DELIVERY OF BIOMOLECULES TO INDUCE TOLERANCE
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United States of America
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Apr 3, 2025
app pub date -
Dec 12, 2024
filing date -
Dec 12, 2024
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Abstract
The present invention provides methods for inducing tolerance and/or suppressing an immune response to an antigen by passing a cell suspension containing an anucleate cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell. In some embodiments, the anucleate cell is delivered to an individual and the antigen is delivered to and processed in a tolerogenic environment to induce tolerance and/or suppress an immune response to the antigen.
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