CHIMERIC ADAPTOR POLYPEPTIDES
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United States of America
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Apr 3, 2025
app pub date -
Oct 27, 2022
filing date -
Oct 27, 2022
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Abstract
Aspects of the disclosure include compositions and methods for treatment of a wide variety of diseases/conditions with engineered host cells. In some embodiments, the engineered host cells comprise a chimeric adaptor (CAD) polypeptide comprising DAP 10. The CAD polypeptide comprises substitution mutations and/or additional protein domains that function in conjunction with associated receptors to enhance cell survival and proliferation of the host cells, and to enhance cell killing activities of non-host cells.
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