ENGINEERED METHIONINE GAMMA LYASE VARIANTS
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United States of America Patent
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Issued Date -
Mar 27, 2025
app pub date -
Sep 5, 2024
filing date -
Sep 5, 2024
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Abstract
The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH<7) conditions. The present invention also relates to the use of the compositions comprising the engineered methionine gamma lyase polypeptides for therapeutic purposes.
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