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Abstract

A preparation method for a high-strength and high-biocompatibility silk fibroin hydrogel scaffold with a biomimetic microstructure for repair and reconstruction of tendons/ligaments. The preparation method includes processing a natural silk fibroin material through directional freezing and coaxial hot stretching. The heating temperature is higher than a glass transition temperature of the silk fibroin material, such that a maximum tensile strength of the silk fibroin hydrogel scaffold increases, a microscopic directional pore structure is formed, and finally a mechanically reinforced hydrogel scaffold with good biocompatibility is obtained. The artificial tendon/ligament scaffold prepared by using the hydrogel scaffold reaches mechanical strength similar to that of the tendons/ligaments in the human body and has good biocompatibility. The microstructure of the scaffold is provided with micron-scale directional pores, helping cells to directionally grow on the surface of the material and inside the material, which achieves high repair efficiency.

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First Claim