ANTIBODY THAT SPECIFICALLY BINDS TO CD7 AND USE THEREOF IN PREPARING CHIMERIC ANTIGEN RECEPTOR

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20250099504A1
SERIAL NO

18730335

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided are an antibody that specifically binds to CD7 and an antigen-binding moiety thereof. The antibody and the antigen-binding moiety thereof have high affinity and high binding specificity for CD7. Also provided are a CD7-targeting chimeric antigen receptor CD7 scFv-CD8α-4-1BB-CD3ζ and a T cell that expresses the chimeric antigen receptor. The T cell can effectively prevent off-target effects.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL CHINESE ACADEMY OF MEDICAL SCIENCESNO 288 NANJING ROAD HEPING DISTRICT TIANJIN 300020

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GU, Runxia Tianjin, CN 1 0
LIAO, Xiaolong Tianjin, CN 3 1
RAO, Qing Tianjin, CN 5 7
WANG, Jianxiang Tianjin, CN 12 25
WANG, Min Tianjin, CN 957 5670
XIE, Leling Tianjin, CN 1 0
YANG, Xue Tianjin, CN 128 1955

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