METHODS OF INHIBITING KLEBSIELLA PNEUMONIAE CARBAPENEMASE-2
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Mar 27, 2025
app pub date -
Sep 22, 2023
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Sep 22, 2023
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Method of at least partially inhibiting the function of Klebsiella pneumoniae carbapenemase-2 (KPC-2) or a variant thereof, the method including contacting the KPC-2 with a benzoxaborole selected from the group consisting of 5-chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, and mixtures thereof useful in the treatment of beta-lactam antibiotic resistant bacteria infections in a subject.
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