INTERFEROMETRIC SCATTERING MICROSCOPY
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United States of America
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Mar 20, 2025
app pub date -
Dec 6, 2024
filing date -
Dec 6, 2024
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Abstract
An interferometric scattering microscope is adapted by performing spatial filtering of output light, which comprises both light scattered from a sample location and illuminating light reflected from the sample location, prior to detection of the output light. The spatial filtering passes the reflected illumination light but with a reduction in intensity that is greater within a predetermined numerical aperture than at larger numerical apertures. This enhances the imaging contrast for coherent illumination, particularly for objects that are weak scatterers.
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