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Abstract

Implementations include methods and systems for recovering an analyte from a tissue sample extracted via a core needle biopsy. The method may involve immersing the core needle holding the tissue sample in a sterilized buffer solution without formalin. Swirling of the needle may dislocate the tissue core and cells for creation of an intermediate mixture. This mixture may be filtered using a strainer into a sample tube to separate the tissue core resulting in another intermediate mixture. Equal volume of a cell lysis and stabilization reagent may be added to this mixture to yield a third mixture containing lysed dislodged cells. The assessable analyte, unexposed to formalin, may then be isolated. The system for this procedure may include a core needle, a buffer container, a sample tube, a strainer and a potential container for tissue core storage. The analyte could be DNA, RNA, an exosome, or a protein.

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First Claim