PHOSPHONIUM-BEARING CONJUGATED POLYELECTROLYTES
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United States of America
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Mar 20, 2025
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Aug 21, 2024
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Aug 21, 2024
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Abstract
A solution is described for therapeutic materials against antibiotic-resistant bacterial strains. A series of four PPE-based water-soluble conjugated polyelectrolytes containing phosphonium side chains of varying amphiphilic balance. The study of the photophysical properties revealed the efficient formation of 102 and ROS for their use as photosensitizers for light-activated antibacterial applications. A photosensitizer absorbs light to produce reactive oxygen species (ROS), and a photodynamic therapy (PDT) is widely used, in which the photosensitizer is excited upon irradiation with light of a specific wavelength from the outside to generate active oxygen species or free radicals, thereby inducing apoptosis of various lesions or cancer cells and destroying them.
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