SMALL MOLECULE INHIBITORS FOR EARLY DIAGNOSIS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN CANCERS AND NEURODEGENERATIVE DISEASES

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United States of America

APP PUB NO 20250090698A1
SERIAL NO

18943338

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Abstract

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Accordingly, embodiments herein disclose a conjugate D-E-F having binding affinity≤60 nM; wherein D comprises AAPT ligand or derivative thereof, E comprises a spacer comprising AA1, AA2, AA3 and/or AA4 and F is a chelating group. The conjugate also comprising AAPT ligand conjugated arene chelating linker for delivery of 99mTc radioisotope. Another embodiment also discloses a AAPT-PCa DOTA bioconjugate. An embodiment also discloses method of solid phase synthesis of AAPT-ligand. It also discloses a method of solid phase synthesis of AAPT-PCa DOTA bioconjugate for delivering of radioisotopes.

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INDIAN INSTITUTE OF TECH INDORENot Provided

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chelvam, Venkatesh Indore, IN 12 119
Krishnan, Mena Asha Indore, IN 3 0
Pandit, Amit Indore, IN 3 0
Sengupta, Sagnik Indore, IN 2 0

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