LYMPHANGIOGENESIS-PROMOTING AGENTS
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United States of America
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Issued Date -
Mar 20, 2025
app pub date -
Sep 18, 2024
filing date -
Sep 18, 2024
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Abstract
Described herein is the discovery that HGFs activate the growth and migration of lymphatic endothelial cells and thereby promote lymphangiogenesis. The present invention is based on this finding, and provides lymphangiogenesis-promoting agents comprising as active ingredients HGFs, or proteins or compounds functionally equivalent thereto. Based on the finding described above, the present invention also provides methods for promoting lymphangiogenesis which comprise the step of locally administering HGFs or proteins functionally equivalent thereto to affected areas in patients with lymphedema.
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