STRAIN OF PEDIOCOCCUS ACIDILACTICI WITH FUNCTION OF TREATING ULCERATIVE COLITIS AND APPLICATION THEREOF
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United States of America
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Mar 20, 2025
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Dec 1, 2024
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Dec 1, 2024
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Abstract
A strain of Pediococcus acidilactici with a function of treating ulcerative colitis and its application are disclosed. The disclosure provides a strain of Pediococcus acidilactici GOLDGUT-PA0755, which can relieve ulcerative colitis, inhibit inflammation and repair intestinal barriers, specifically in: relieving the weight loss, colon length ratio reduction and DAI score increase caused by DSS of ulcerative colitis model mice, reducing the rise of the serum inflammatory factor level and the rise of the ratio of the inflammatory factor to the anti-inflammatory factor caused by DSS of ulcerative colitis model mice, recovering the injury of colonic mucosa caused by DSS of ulcerative colitis model mice, reducing the decrease of anti-inflammatory factors and the increase of the ratio of the inflammatory factor to the anti-inflammatory factor caused by the DSS of PBMC cells, and restoring the content of the tight junctional protein ZO-1 in inflammation injury model of monolayer epithelium.
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