STABLE HIGH CONCENTRATION SODIUM CHLORIDE FORMULATIONS CONTAINING PD-1 ANTIBODY AND METHODS OF USE THEREOF

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United States of America

APP PUB NO 20250084168A1
SERIAL NO

18910935

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Abstract

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The present invention relates generally to the field of pharmaceutical formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The formulations may further contain a histidine buffer, an inorganic salt, a sugar polyol, and a non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit low viscosity and a substantial degree of antibody stability after being subjected to thermal and other physical stress. Also provided are methods of making and methods of using such antibody formulations.

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Patent Owner(s)

Patent OwnerAddress
BEIGENE SWITZERLAND GMBHAESCHENGRABEN 27 BASEL 4051

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GU, Sufang Suzhou,, CN 2 0
JI, Yu Suzhou,, CN 25 86
JIN, Xiaoqing Suzhou,, CN 9 7
QIU, Bo Guangzhou,, CN 56 456
SHEN, Jian Suzhou,, CN 161 1375
WU, Jun Suzhou,, CN 507 5138

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