POLYPEPTIDE HAVING EFFECT OF INHIBITING PROLIFERATION OF LEUKEMIA CELLS
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United States of America
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Mar 13, 2025
app pub date -
Mar 7, 2019
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Mar 7, 2019
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Abstract
The present disclosure discloses a polypeptide having an effect of inhibiting the proliferation of leukemia cells, and particularly relates to use of the polypeptide in a drug for treating leukemia. The polypeptide consists of 37 amino acids, with the amino acid sequence thereof being Lys-Glu-Ser-Met-Asp-Ala-Asn-Lys-Pro-Thr-Lys-Asn-Leu-Pro-Leu-Lys-Lys-Ile-Pro-Cys-Lys-Thr-Ser-Ala-Pro-Ser-Gln-Ser-Phe-Phe-Ala-Arg-Asp-Asn-Thr-Ala-Asn, and the N-terminus of the polypeptide being conjugated with myristate. The polypeptide prepared by the present disclosure can enter the leukemia cells by conjugating with the myristic acid, thereby achieving the effect of inhibiting the proliferation of the leukemic cells.
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