TRANSDERMAL INSULIN FORMULATIONS AND METHODS OF USE THEREOF
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United States of America
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Mar 13, 2025
app pub date -
Sep 8, 2022
filing date -
Sep 8, 2022
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Abstract
Pharmaceutical formulations for the transdermal administration of insulin by topical application of the formulation to the skin of humans or other animals are described. Methodology for formulating such formulations which provide for very rapid uptake of the insulin and transmigration into and through the skin to either fatty tissues or the vascular system, while minimizing irritation to the skin and/or immunological response, is based on a transdermal delivery system wherein the insulin forms a true solution in a complex formed from particular solvents and solvent and solute modifiers in combination with skin stabilizers. Uptake of the medicament is further facilitated and made more rapid by including Forskolin or other source of cellular energy, namely induction of cAMP or cGMP.
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