METHODS FOR CHARACTERIZING A PROTEIN OF INTEREST

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United States of America

APP PUB NO 20250076307A1
SERIAL NO

18817850

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods can be conducted to prevent disulfide scrambling in liquid chromatography-mass spectrometry analysis of a protein of interest. In particular, methods can be conducted by employing a NEM analog, such as maleimide, and a heavy isotope counterpart of the NEM analog, such as a heavy isotope substituted maleimide, to alkylate a protein of interest and to alkylate a peptide digest of the protein of interest under conditions that prevent disulfide scrambling and subjecting the samples to a liquid chromatography-mass spectrometry analysis.

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Patent Owner(s)

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REGENERON PHARMAUSA NEW YORK

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  • 2024 Application Filing Year
  • C12Q Class
  • 1740 Applications Filed
  • 69 Patents Issued To-Date
  • 3.97 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Andrew, KLEINBERG Roslyn, US 1 0
Ning, LI New Canaan, US 11 22
Yuan, MAO Hartsdale, US 9 18

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