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Abstract

System and methods for continuous culture comprise performing a first continuous culture of cells in a chamber of a first bioreactor under culture conditions that produce cell growth; moving culture fluid comprising cells from the chamber of the first bioreactor into a chamber of a second bioreactor though one or more fluidic conduits; and performing, in the chamber of the second bioreactor, a second continuous culture of cells under culture conditions that produce at least one culture product. The process is performed under conditions wherein the rate of cell growth in the first continuous culture is greater than that of the second continuous culture, and the production of culture product in the first continuous culture is less than that of the second continuous culture.

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First Claim