NANOPARTICLES COMPRISING FUSION PROTEIN OF SINGLE-CHAIN VARIABLE FRAGMENT AND FERRITIN, AND USE THEREOF
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United States of America
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Mar 6, 2025
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May 9, 2022
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May 9, 2022
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Abstract
The present invention provides: ferritin; a single-chain variable fragment bound to the N-terminus of the ferritin; and a fusion protein self-assembling nanoparticle structure in which an N-terminus RNA-interaction domain (RID) in a human-derived lysyl-tRNA synthetase is bound to the N-terminus of the single-chain variable fragment by means of a novel fusion partner. Therefore, the present invention provides: a fusion protein having enhanced water solubility; nanoparticles; a vector coding same; a host cell transformed by means of the vector, and a pharmaceutical composition, for treating a disease, using the same.
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