CHIMERIC CD40 POLYPEPTIDES AND METHODS OF USE IN IMMUNOTHERAPY
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United States of America
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Mar 6, 2025
app pub date -
Jan 4, 2023
filing date -
Jan 4, 2023
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Abstract
Modified T cells comprising ectopic CD40 proteins (such as chimeric CD40 proteins including a CD40 extracellular domain and a heterologous intracellular domain) are provided. Also provided are compositions, including pharmaceutical formulations, comprising the modified T cells, and methods for increasing T cell-mediated tumor cell-specific cytotoxicity using the same. Methods of treating a subject with cancer including administering to the subject the modified T cells, thereby activating an innate immune response and/or an adaptive immune response in the subject are also provided.
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