PREKALLIKREIN-MODULATING COMPOSITIONS AND METHODS OF USE THEREOF
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United States of America
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Issued Date -
Mar 6, 2025
app pub date -
May 24, 2024
filing date -
May 24, 2024
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Abstract
Aspects of the disclosure provide compounds, compositions, and methods for modulating the expression or activity of plasma prekallikrein (PKK). In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK mRNA in a cell or animal. In some aspects, the compounds, compositions, and methods of the disclosure can be used to reduce the expression of PKK protein in a cell or animal.
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