Importance

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Abstract

Apparatus and associated methods relate to a weight reduced ferrule (WRF) pharmaceutical container closure system that consumes less resources while having sufficient tensile strength to sealingly couple a closure to a canister. The pharmaceutical canister may, for example, include a lip extending into a cavity of the container from a distal end of the wall at a predetermined angle. The lip may, for example, define a sealing flat sealing surface extending around an entire perimeter of an aperture into the cavity. The WRF canister may, for example, include a validation method including a placement of a pharmaceutical container within a vacuum chamber including a sensor. The method includes a correlation of a pharmaceutical leakage calibration to the sensor. The method includes a validation determination as a function of the predetermined correlation between a detection of a leaked substance and a weight change in the pharmaceutical canister over a predetermined period.

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First Claim