THERAPEUTIC OLIGONUCLEOTIDES HAVING AN INTER-NUCLEOSIDE AMIDE LINKAGE
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United States of America
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Feb 20, 2025
app pub date -
Dec 16, 2022
filing date -
Dec 16, 2022
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Abstract
The present invention relates to a therapeutic oligonucleotide having a 5′ and a 3′ end and comprising a sequence of nucleosides linked together by inter-nucleoside linkages, wherein: at least one inter-nucleoside linkage is an amide linker moiety; at least one inter-nucleoside linkage is a phosphorothioate linker moiety; and at least one nucleoside present in the oligonucleotide is a locked nucleoside; wherein the at least one locked nucleoside is directly attached to the 3′ end or the 5′ end of the amide linker moeity. The oligonucleotide has preferably structure (IIa) or (llb):
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