CH1 DOMAIN AFFINITY LIGANDS AND AGENTS
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United States of America
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Issued Date -
Feb 20, 2025
app pub date -
Dec 23, 2022
filing date -
Dec 23, 2022
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Abstract
The present disclosure relates to the field of chromatography, and more specifically to novel affinity ligands and affinity agents which are suitable for use in isolation of antibody and antibody fragments that contain the heavy chain first constant region (CHI). The disclosure encompasses affinity ligands as such, chromatography separation matrices (affinity agents) comprising an affinity ligand according to the disclosure, and a process of isolating antibodies, especially IgGs, and CHI-containing antibody fragments thereof using an affinity ligand according to the disclosure. Methods of making the affinity ligands and separation matrices are also provided.
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