Compositions and Methods for Selective Labeling of Secondary Amines
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United States of America
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Feb 20, 2025
app pub date -
Dec 16, 2022
filing date -
Dec 16, 2022
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Abstract
This disclosure relates to compositions and methods for selective labeling of aliphatic or aromatic secondary amines. In certain embodiments, the secondary amines are N-methyl lysine, N-terminal proline, N-alkyl lysine, N-alkyl adenosine, N-alkyl cytosine, or peptides and nucleic acids containing the same. In certain embodiments, this disclosure relates to methods of forming 2-indazol-3-carbonyl labeled compounds, benzotriazole labeled compounds, or carbamodithioate labeled compounds comprising contacting a compound containing a secondary amine group with agents disclosed herein.
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