Chemical Activators of Nicotinamide Mononucleotide adenylyltransferase 2 (NMNAT2) and Uses Thereof

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United States of America

APP PUB NO 20250059160A1
SERIAL NO

18938755

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Abstract

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The present disclosure relates to novel NMNAT2 activators, semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the method by administering the novel semicarbazones and thiosemicarbazones for the treatment and/or prevention of diseases and to the use thereof for the production of a medicament for the treatment and/or prevention of diseases, especially neurodegenerative and age-associated diseases or conditions associated with NAD loss. The present disclosure also provides a method for high throughput screening of NMNAT2 activators.

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  • 2024 Application Filing Year
  • A61K Class
  • 9279 Applications Filed
  • 536 Patents Issued To-Date
  • 5.78 % Issued To-Date
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Inventor Name Address # of filed Patents Total Citations
Chen, Shuangquan Beijing City, CN 11 5
Tang, Yefeng Beijing City, CN 2 0
Wang, Gelin Beijing City, CN 6 27
Wang, Leibo Beijing City, CN 2 0
Zhang, Ruoxi Beijing City, CN 4 0

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