COMPOSITIONS AND METHODS FOR DIAGNOSIS, TREATMENT OF AND PREVENTION OF KIDNEY DISEASE
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United States of America
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Feb 13, 2025
app pub date -
Dec 20, 2022
filing date -
Dec 20, 2022
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Abstract
Disclosed herein are methods of detecting xanthine oxidase expression in polycystic kidney disease, or methods of delaying the onset or treating polycystic kidney disease, or both. The inventors have made the remarkable discovery that aberrant purine metabolism is not a corollary to disease but rather tissue expression of xanthine oxidase/xanthine dehydrogenase (XO/XDH) expression is increased and possibly uric acid and oxygen radical production acting alone or in combination acts as a primary mediator of progression of structural and functional dysfunction. Specifically exemplified are methods that involve, measuring and evaluating tissue XO/XDH expression in polycystic kidney disease or any cystic tissue. Moreover, specifically exemplified are methods that involve administering to a patient susceptible to development of polycystic kidney disease a composition of agents, including uric acid lowering agents in a regimen that decreases expression of XO/XDH, lowering intracellular uric acid or free oxygen radical expression in a tissue.
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