CD123 ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THE SAME

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United States of America

APP PUB NO 20250051463A1
SERIAL NO

18785065

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present disclosure generally relates to antibodies, antigen binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukin-3 receptor) and deliver a payload to CD123 expressing cells. The payload is a topoisomerase inhibitor that efficiently kills CD123 expressing tumor cells while sparing hematopoietic stem cells and mature hematopoietic cells.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
ANDRADE, CAMPOS Marcio Cambridge, GB 1 0
DANIELS, Casey Gaithersburg, US 2 6
DUTTA, Dipannita Gaithersburg, US 1 0
FLEMING, Ryan Gaithersburg, US 24 97
GORGUN, Gullu Waltham, US 3 0
PAN, Pan Gaithersburg, US 32 120

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