BOTTLEBRUSH CONJUGATES FOR USE AS OLIGONUCLEOTIDE ENHANCERS
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United States of America
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Feb 13, 2025
app pub date -
Dec 16, 2022
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Dec 16, 2022
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Abstract
Provided herein are, in various embodiments, are bottlebrush polymer-oligonucleotides conjugates. In certain embodiments, the conjugates are potent in vivo, have improved biopharmaceutical properties, enhanced transfection efficiency, and/or an unconventional biodistribution profile. Also provided herein are pharmaceutical compositions, methods of treatment, and methods of making bottlebrush polymer-oligonucleotide conjugates.
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