METHODS AND COMPOSITIONS FOR ALTERING A TUMOR MICROBIOME
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United States of America
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Issued Date -
Feb 13, 2025
app pub date -
Dec 15, 2022
filing date -
Dec 15, 2022
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Abstract
Aspects of the present disclosure relate to methods and compositions for altering a tumor microbiome. Certain aspects are directed to methods for manipulating a tumor microenvironment for promotion of a tumor restraining microbiome and treatment of cancer. Particular aspects include methods for treating cancer comprising administration of an immunotherapy and an agent capable of disrupting an interaction between α3β1 integrin and α1 homotrimeric type I collagen.
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