CROSSLINKING AGENTS AND MEDICAL HYDROGELS FORMED THEREFROM
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United States of America
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Issued Date -
Feb 6, 2025
app pub date -
Jul 23, 2024
filing date -
Jul 23, 2024
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Abstract
In some aspects, the present disclosure pertains to methods that comprise (a) performing a ring-opening polymerization of one or more types of amino acid N-carboxyanhydride (NCA) monomers that comprise at least one type of protected amino acid NCA monomer having a protected pendant amine group in the presence of an initiator compound to produce intermediate peptide compounds that comprise an amino acid chain having protected pendant amine groups covalently attached to a residue of the initiator and (b) deprotecting the intermediate peptide compounds to form final peptide compounds that comprise an amino acid chain having pendant amine groups covalently attached to the residue of the initiator.
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