RAPID, GREEN, DISULFIDE BOND FORMATION IN WATER USING DICYANOCOBINAMIDE

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United States of America

APP PUB NO 20250042937A1
SERIAL NO

18792216

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Abstract

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Methods and compositions are provided for oxidizing peptides and forming disulfide bonds. In some aspects, a rapid, green, and facile oxidation of peptides (e.g., cysteine containing peptides) is performed (e.g., to promote the formation of 1-3 or more disulfide bonds). In some aspects, methods are conducted in aqueous solutions, in air, utilizing a biocompatible corrin ring-containing compound (e.g., dicyanocobinamide). In some aspects, reaction times are under 1 hour and a simple one step removal of the catalyst can be performed.

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  • SYRACUSE UNIVERSITY

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Inventor Name Address # of filed Patents Total Citations
Doyle, Robert Manlius, US 23 48
Spear, Alyssa Cazenovia, US 1 0

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