RAPID, GREEN, DISULFIDE BOND FORMATION IN WATER USING DICYANOCOBINAMIDE
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United States of America
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Issued Date -
Feb 6, 2025
app pub date -
Aug 1, 2024
filing date -
Aug 1, 2024
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Abstract
Methods and compositions are provided for oxidizing peptides and forming disulfide bonds. In some aspects, a rapid, green, and facile oxidation of peptides (e.g., cysteine containing peptides) is performed (e.g., to promote the formation of 1-3 or more disulfide bonds). In some aspects, methods are conducted in aqueous solutions, in air, utilizing a biocompatible corrin ring-containing compound (e.g., dicyanocobinamide). In some aspects, reaction times are under 1 hour and a simple one step removal of the catalyst can be performed.
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Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
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- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
- SYRACUSE UNIVERSITY
International Classification(s)
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Doyle, Robert | Manlius, US | 23 | 48 |
# of filed Patents : 23 Total Citations : 48 | |||
Spear, Alyssa | Cazenovia, US | 1 | 0 |
# of filed Patents : 1 Total Citations : 0 |
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