CYCLIC DINUCLEOTIDES AS AGONISTS OF STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING

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United States of America

APP PUB NO 20250041324A1
SERIAL NO

18734176

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Abstract

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Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CURRAN, Michael A Pearland, US 23 171
DI, FRANCESCO Maria Emilia Houston, US 49 489
JONES, Philip Houston, US 185 1433

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