TUNABLE ELECTROOSMOTIC FLOW POLYMER COATED CAPILLARY

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250035587A1
SERIAL NO

18914910

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Abstract

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A surface-confined aqueous reversible addition-fragmentation chain transfer (SCARAFT) polymerization method was developed to coat capillaries for use in capillary zone electrophoresis (CZE). This coating produced an electroosmotic an order of magnitude lower than that of commercial linear polyacrylamide (LPA)-coated capillaries. Coated capillaries were evaluated for bottom-up proteomic analysis using CZE. The very low electroosmotic mobility results in a 200 min separation and improved single-shot analysis. Various types of coatings were prepared by simply changing the functional vinyl monomers in the polymerization mixture.

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Patent Owner(s)

  • UNIVERSITY OF NOTRE DAME DU LAC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DOVICHI, Norman South Bend, US 12 107
ZHANG, Zhenbin South Bend, US 5 0

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