IL-21 POLYPEPTIDES AND TARGETED CONSTRUCTS
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United States of America
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Jan 30, 2025
app pub date -
Oct 14, 2024
filing date -
Oct 14, 2024
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Abstract
The present disclosure provides methods and compositions comprising IL-21 polypeptides, targeted cytokine construct that selectively activates target immune cells (e.g., CD8+ T cells) over other immune cell types. The cytokine of the present disclosure can further comprise mutations that alter its charge distribution to improve its half-life within the blood.
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