PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250034157A1
SERIAL NO

18913645

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Abstract

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The present disclosure relates to solid-state forms and corresponding pharmaceutical compositions of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, and methods of treatment, including treatment of rheumatoid arthritis and juvenile idiopathic arthritis using the same. The treatment methods generally comprise administering to a patient (e.g., a pediatric patient) a therapeutically effective amount of upadacitinib as a stable liquid pharmaceutical composition or a solid dosage form, at a dose based on patient body weight.

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ABBVIE INC1 NORTH WAUKEGAN ROAD NORTH CHICAGO IL 60064

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allian, Ayman Newbury Park, US 37 476
Bhagavatula, Lakshmi Vernon Hills, US 37 295
Borchardt, Thomas B Kenosha, US 55 529
Camp, Heidi S Winnetka, US 17 127
Jayanth, Jayanthy Buffalo Grove, US 49 703
Klünder, Ben Ludwigshafen, DE 46 718
Marroum, Patrick J Springfield, US 42 656
Mayer, Peter T Libertyville, US 52 696
Mohamed, Mohamed-Eslam F Gurnee, US 53 876
Mulhern, Mathew M Lake Villa, US 36 371
Nordstrom, Fredrik Lars Ridgefield, US 38 290
Othman, Ahmed A Libertyville, US 52 899
Padley, Robert J Highland Park, US 27 211
Rozema, Michael J Kenosha, US 34 259
Sheikh, Ahmad Y Lake Forest, US 55 561
Voss, Jeffrey W Hudson, US 40 1081

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