HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE
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United States of America
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Jan 30, 2025
app pub date -
Oct 4, 2022
filing date -
Oct 4, 2022
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Abstract
The invention provides heterobifunctional compounds comprising an effector protein binding moiety selected from mTor, PLK1, CDK1, CDK2, CDK9, BRD4, AURKA, AURKB, MEK, Src, c-KIT, KIF11, HSP90, tubulin, proteasome, topoisomerase or HD AC which is linked to a moiety that binds to a target protein selected from BTK, androgen receptor or IDH1. Pharmaceutical compositions and their use in treating disease, such as cancer, are also disclosed.
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