Attenuated Bordetella Strains
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United States of America
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Issued Date -
Jan 30, 2025
app pub date -
Aug 17, 2024
filing date -
Aug 17, 2024
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Abstract
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
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