T7 RNA POLYMERASE VARIANTS
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United States of America Patent
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Jan 23, 2025
app pub date -
Oct 8, 2024
filing date -
Oct 8, 2024
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Abstract
The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
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