Intermittent Percolation Washing
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United States of America Patent
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Issued Date -
Jan 23, 2025
app pub date -
Oct 16, 2022
filing date -
Oct 16, 2022
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Abstract
The present invention relates to a process for the displacement of compounds and solvents comprised in the liquid and solid phase of a heterogeneous liquid-solid phase reaction, such as a solid phase peptide synthesis (SPPS) or solid phase oligonucleotide synthesis (SPOS). The process is applied in a reactor comprising a liquid phase and a solid phase, to which reactor a displacement liquid is fed discontinuously while the liquid phase is removed from the reactor chamber. The invention also encompasses a process for synthesizing peptides or oligonucleotides by the application of a solid phase peptide or oligonucleotide synthesis protocol further comprising the process for the displacement of compounds.
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