Methods and Compositions for Xenotransplantation
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United States of America Patent
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Issued Date -
Jan 23, 2025
app pub date -
Sep 1, 2022
filing date -
Sep 1, 2022
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Abstract
Provided herein are methods of xenotransplantation, for example, porcine to human transplantation. Also provided herein are extracellular vesicles (“EVs”, e.g., exosomes) and compositions comprising the same. e.g. EVs expressing human CD47. Further provided herein are methods of making EVs and use thereof for xenotransplantation. In some aspects, the methods of xenotransplantation comprise steps of expressing human CD47 on xenografts.
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