METHODS FOR SYNTHESIZING AND IDENTIFYING SYNTHETIC PROTEINS INCLUDING TARGETED THERAPEUTICS FOR NEURODEGENERATIVE DISORDERS BASED ON BIO-MIMICRY APPROACHES
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United States of America
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Jan 16, 2025
app pub date -
Jul 11, 2024
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Jul 11, 2024
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Abstract
A method for synthesizing a synthetic molecule includes selecting a target protein, selecting a common precursor, providing first and second side-chains, forming a first monomer, including the common precursor and first side-chain, forming a second monomer, including the common precursor and second side-chain, evaluating the first and second monomers using an aggregation assay with the target protein to generate first results, and selecting one of the first and second monomers as a selected monomer based on the first results. Further, the method includes providing third and fourth monomers compatible with the selected monomer, forming a first dimer, including the selected monomer and third monomer, forming a second dimer, including the selected monomer and fourth monomer, evaluating the first and second dimers with the aggregation assay to generate second results, and selecting one of the first and second dimers as a selected dimer based on the second results.
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