SELECTIVE OXIDATION OF 5-METHYLCYTOSINE BY TET-FAMILY PROTEINS

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United States of America

APP PUB NO 20250019747A1
SERIAL NO

18894673

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Abstract

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The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agarwal, Suneet Belmont, US 50 770
Iyer, Aravind Bethesda, US 42 837
Koh, Kian Peng Jamaica Plain, US 39 747
RAO, Anjana La Jolla, US 75 871
Tahiliani, Mamta New York, US 39 747

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