METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION

Number of patents in Portfolio can not be more than 2000

United States of America

APP PUB NO 20250018047A1
SERIAL NO

18705615

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Abstract

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Provided are PROTACs comprised of a targeting moiety designed to bind KRAS (G12D) linked to a degrader-directing moiety designed to bind an E3 ubiquitin-ligase. Pharmaceutical compositions comprising the disclosed PROTACs and their use in treating cancer and related conditions are also provided.

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Patent Owner(s)

Patent OwnerAddress
RANOK THERAPEUTICS (HANGZHOU) CO LTDFLOOR 4 BUILDING 16 HEXIANG SCIENCE TECHNOLOGY CENTER QIANTANG DISTRICT HANGZHOU 310018

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Foley, Kevin P Waltham, US 21 39
Prince, Thomas Danville, US 3 0
Wang, Mingkai Hangzhou, CN 5 0
Wang, Yaya Shanghai, CN 3 0
Ye, Long Shanghai, CN 37 177
Yin, Wei Lianyungang, CN 81 329
Ying, Chenghao Shanghai, CN 6 0
Ying, Weiwen Lexington, US 100 1571
Zhang, Lingjie Wuxi, CN 13 0

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