SEQUENCING AND STRATEGIES FOR ENHANCING INTRAVASCULAR THROMBUS DISRUPTION WITH PHASE-CHANGE CAVITATION ENHANCING AGENTS
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United States of America
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Issued Date -
Jan 16, 2025
app pub date -
Dec 1, 2022
filing date -
Dec 1, 2022
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Abstract
A method for disrupting a blood clot with ultrasound and at least one cavitation enhancing agent includes administering at least one cavitation enhancing agent into a blood vessel of a subject. The method further includes monitoring the at least one cavitation enhancing agent to determine when at least a portion of the at least one cavitation enhancing agent has reached a blood clot. The method further includes controlling application of ultrasound energy to the at least one cavitation enhancing agent within the blood vessel of the subject such that, during a first time period, cavitation-enhancing ultrasound energy is not applied to the at least one cavitation enhancing agent within the blood vessel and, during a second time period after the first time period, cavitation enhancing ultrasound energy is applied to the at least one cavitation enhancing agent within the blood vessel.
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