PRODUCTS AND USES THEREOF FOR PREDICTING THE SENSITIVITY OF A SUBJECT TO CANCER IMMUNOTHERAPY AND FOR SELECTING OPTIMIZED THERAPY
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United States of America
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Issued Date -
Jan 9, 2025
app pub date -
Nov 10, 2022
filing date -
Nov 10, 2022
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Abstract
The present invention relates to a method of predicting, assessing or monitoring the sensitivity of a subject having a cancer to an immunotherapy, preferably to an immunotherapy combining at least two immunotherapeutic agents, and to corresponding kits and uses thereof. The method of predicting, assessing or monitoring the sensitivity of a subject having a tumor to an immunotherapy typically comprises a step of assessing, before any immunotherapeutic treatment step in the subject, the presence of CD4+CD25highCD39high T cells in a tumor sample of the subject, the presence of CD4+CD25highCD39high T cells in the tumor sample of the subject being indicative of sensitivity of the subject to the immunotherapy, and the absence of CD4+CD25highCD39high T cells in the tumor sample of the subject being indicative of resistance of the subject to the immunotherapy.
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