MOLECULAR DETECTION USING BARCODE PROBES OR BARCODE FUSION PROBES AND HYBRIDIZATION CHAIN REACTION
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United States of America
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Jan 9, 2025
app pub date -
Jul 3, 2024
filing date -
Jul 3, 2024
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Abstract
The present application relates to hybridization chain reaction (HCR). The sensitivity and multiplexing of hybridization chain reaction (HCR) signal amplification are combined with target detection using barcode probes or barcode fusion probes, wherein a barcode probe or barcode fusion probe comprises a primary probe (comprising a target-binding domain) bound to a secondary probe (comprising a primary-probe-binding-domain and a barcode oligonucleotide comprising an HCR initiator or an HCR fractional initiator).
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